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The Quest for Immortality: Would You Want to Live Forever?

A big part of our culture, the global culture that is, lies in the process of aging, of growing o...

The Quest for Immortality: Would You Want to Live Forever?

A big part of our culture, the global culture that is, lies in the process of aging, of growing old. It’s difficult to edify, just how much of our lives are dedicated to understanding, worrying about, coping with and trying to defeat the aging process. The sands of time, as they say, never stop flowing. And far be it for me to start a discussion on the direction and essence of time. No, I’ve something much more complicated to talk about today.

Senescence.

No, that’s not some new anti-ageing cream. That’s the very contrived and scientific word for growing old. More specifically it describes the gradual biological deterioration of cellular function, which in most living things means that after maturation, the entity in question experiences increased mortality in step with the passage of time.

The Quest for Immortality: Would You Want to Live Forever?

It is senescence that causes your wrinkles and grey hairs and your stubborn spare tire, indirectly that is. It is the unavoidable process that allows the direct causes of those maladies to come about. And it is that unavoidable process that some people wish to…avoid.

Since the beginning of time, it seems, mankind has sought the key to immortality. Whether that be through the fountain of youth – one of Sir Isaac Newton’s favourite musings – or, more recently, through the efforts of the transhumanist society, who see things in a slight bit more realistic terms, but we’ll get to that.

Senescence doesn’t apply to all living creatures though, amazingly enough. There are certain taxa, mostly plants, but some animals as well, who do not suffer from an increased mortality as they age. In fact there are some forms of life that undergo a defined decrease in mortality the older they get. These rare creatures, as they mature from whatever prepubescent or larval form they initially hold, retain the ability to revert back into a pre-mature state of being, which by-passes the process of senescence altogether.

The Quest for Immortality: Would You Want to Live Forever?

Some species of crab and lobster have this ability, as do a few others in the genus arthropoda, and there are several species of tree, fungus and shrubbery that exhibit an impressive resistance to time’s assault.

The reason for this highly coveted ability isn’t well understood. In fact, the reason for the reason for this ability is something of a mystery too. How it works, senescence that is – or biogerontology, if you prefer – is somewhat understood, in that there are many highly complex and hotly debated theories of senescence on the books at the moment, from Gene Regulation Theory to Chemical and/or DNA Damage theories. It’s generally accepted that there is something inherent to biology that affects the efficiency of cellular replication throughout the lifecycle of any creature, it’s just, what that something is, isn’t readily agreed upon.

Here’s where it gets really interesting.

Medical science has studied this process and its attendant features for decades, in pursuit of both cosmetic cure-alls and more humane means of improving the length and quality of life. Human life that is. Some have taken that effort up as a sort of mantra, and have labelled their cause transhumanism. That is, whatever your preconceived understanding of the term may be, a concerted effort to defeat the sands of time and the effect they have on the human body. In short, they – transhumanists that is – wish to find a way to achieve immortality.

The Quest for Immortality: Would You Want to Live Forever?

That’s a loaded word though, among a loaded sentence for that matter. We aren’t talking about the science fiction, romanticised notion of immortality. We aren’t talking about the Q from Star Trek, much as they might appreciate the sentiment. We’re talking about extending the lifespan of humans to an indefinite degree, through various technological and scientific means.

Quite often the goals of transhumanism are thought of in terms of cybernetics, a merging of technology and biology in an effort to find some permanence of life, though there are other means on the table. A new documentary film making rounds through the film festival circuit, The Immortalists, chronicles the quest of two transhumanist advocates and scientists as they seek out answers to the problem of senescence and ways to achieve immortality.

These men, William H. Andrews and Aubrey de Grey, whom are showcased in the film, approach the problem from drastically different positions. Andrews has studied biological methods of achieving a similar reversing of increased mortality, in much the same way as the species mentioned above. He believes that an artificial extension of telomeres in our DNA are the answer.

In the simplest terms, telomeres, which are the caps on the ends of DNA strands, appear to shorten as we age. Some researchers believe there is a direct correlation between this telomere shortening and senescence, and it follows, at least according to Andrews, that halting and/or reversing this shortening process will inherently alter or stop the aging process. He is currently seeking means to develop chemical medications that will reinforce telomeres, in effect making the patient immortal, of a fashion.

De Grey however, is taking a more space-age approach to the issue. He is calling for funding to further his research into medical nanotechnology. More specifically, he believes the answer is to develop and deploy microrobots that will work in the patient’s blood stream to repair and even replace damaged or aged cells, effectively, though artificially, sidestepping the aging process.

The Quest for Immortality: Would You Want to Live Forever?

That’s a loaded word though, among a loaded sentence for that matter. We aren’t talking about the science fiction, romanticised notion of immortality. We aren’t talking about the Q from Star Trek, much as they might appreciate the sentiment. We’re talking about extending the lifespan of humans to an indefinite degree, through various technological and scientific means.

Quite often the goals of transhumanism are thought of in terms of cybernetics, a merging of technology and biology in an effort to find some permanence of life, though there are other means on the table. A new documentary film making rounds through the film festival circuit, The Immortalists, chronicles the quest of two transhumanist advocates and scientists as they seek out answers to the problem of senescence and ways to achieve immortality.

These men, William H. Andrews and Aubrey de Grey, whom are showcased in the film, approach the problem from drastically different positions. Andrews has studied biological methods of achieving a similar reversing of increased mortality, in much the same way as the species mentioned above. He believes that an artificial extension of telomeres in our DNA are the answer.

In the simplest terms, telomeres, which are the caps on the ends of DNA strands, appear to shorten as we age. Some researchers believe there is a direct correlation between this telomere shortening and senescence, and it follows, at least according to Andrews, that halting and/or reversing this shortening process will inherently alter or stop the aging process. He is currently seeking means to develop chemical medications that will reinforce telomeres, in effect making the patient immortal, of a fashion.

De Grey however, is taking a more space-age approach to the issue. He is calling for funding to further his research into medical nanotechnology. More specifically, he believes the answer is to develop and deploy microrobots that will work in the patient’s blood stream to repair and even replace damaged or aged cells, effectively, though artificially, sidestepping the aging process.

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